Triclosan is an antibiotic and antifungal. It is an inhibitor of E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V, IC50s = 2 and 10 µM, respectively). Triclosan is active against the bacteria M. epidermidis, M. lysodeikticus, S. aureus,...

Triclosan is a diarylether antimicrobial often found in commercial soap products. Triclosan exhibits antibacterial, antifungal, antiviral, and anti-inflammatory activities. Triclosan binds bacterial enoyl-acer carrier protein reductase (ENR), increasing its affinity for NAD+ and forming a complex that prevents fatty...