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Item number: Cay29958-10

ML-SA1 is an agonist of transient receptor potential mucolipin 1 (TRPML1). It induces cytosolic calcium increases in HEK293T cells expressing surface-expressed mutant TRPML1 channels when used at a concentration of 10 µM. ML-SA1 activates TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by...

Keywords:	Mucolipin synthetic agonist 1, 2-[2-(3,4-dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Application:	Mucolipin-1 (TRPML1) agonist
CAS	332382-54-4
MW:	362.4 D

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ML-SA1

Item number: TGM-T23004-100mg

Description: ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 µM and 52.99 µM, respectively[1]. Target: TRP/TRPV...

Keywords:	Mucolipin synthetic agonist 1
CAS	332382-54-4
MW:	362.42 D

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