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Item number: Cay22138-1

MRT10 is an antagonist of the Smoothened (Smo) receptor with an IC50 value of 0.64 µM in a luciferase reporter assay. It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 µM) when expressed in HEK293 cells.Formal Name:...

Keywords:	N-[[[3-(benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxy-benzamide
Application:	Smo antagonist
CAS	330829-30-6
MW:	465.5 D

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MRT-10

Item number: TGM-T23027-100mg

Description: MRT-10 is a Smoothened (Smo) receptor antagonist. Target: Hedgehog/Smoothened. Smiles: COc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1cccc(NC(=O)c2ccccc2)c1. References: Solinas et al (2012) Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 55 1559

CAS	330829-30-6
MW:	465.52 D

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