Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation,...

Description: PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor, which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21µm). PTP Inhibitor IV inhibited SHP-2, PTP1B, PTp-epsilon, PTP Meg-2, PTP-sigma, PTP-beta and PTP-µ, IC50 were 1.8 µM, 2.5 µM, 8.4 µM, 13 µM, 20 µM, 6.4 µM,...