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Item number: Cay39528-1

Col003 is an inhibitor of the protein-protein interaction between collagen and heat shock protein 47 (Hsp47, IC50 = 1.8 µM). It decreases procollagen secretion from, and reduces the collagen levels in the extracellular matrix (ECM) of, primary mouse embryonic fibroblasts (MEFs) when used at a concentration of 100...

Keywords:	2-hydroxy-3-nitro-5-(phenylmethyl)-benzaldehyde
Application:	Collagen-Hsp47 protein-protein interaction inhibitor
CAS	328565-16-8
MW:	257.2 D

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Col003

Item number: TGM-T10860-100mg

Description: Col003 is a selective and potent inhibitor of Hsp47, competitively binding to the collagen-binding site on Hsp47 (IC50: 1.8 µM). It is useful for researching fibrosis. Target: HSP. Smiles: Oc1c(C=O)cc(Cc2ccccc2)cc1[N+]([O-])=O. References: Ito S, et al. A small-molecule compound inhibits a...

CAS	328565-16-8
MW:	257.24 D

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