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AG-14361
Item number: Cay24677-1
AG-14361 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1, Ki = 6.3 nM for the human enzyme). It inhibits PARP1 activity in permeabilized and intact SW620 cells (IC50s = 29 and 14 nM, respectively). AG-14361 (0.4 µM) potentiates the growth inhibitory effects of temozolomide (Cay-14163) in HCT116, A2480, and...
| Keywords: | 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one |
| Application: | PARP1 inhibitor |
| CAS | 328543-09-5 |
| MW: | 320.4 D |
From 67.00€
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AG-14361
Item number: BPS-27602-1
AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy. AG14361 enhances the growth-inhibitory and cytotoxic effects of topoisomerase I poisons...
| Keywords: | 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one, |
| Application: | PARP inhibitor |
| CAS | 328543-09-5 |
| MW: | 320.4 D |
From 453.00€
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AG14361
Item number: TGM-T6339-100mg
Description: AG14361 is an effective inhibitor of PARP1 (Ki<5 nM). Target: PARP. Smiles: CN(C)Cc1ccc(cc1)-c1nc2cccc3C(=O)NCCn1c23. References: Calabrese CR, et al. J Natl Cancer Inst, 2004, 96(1), 56-67.
| Keywords: | AG-14361, AG 14361 |
| Application: | PARP inhibitor |
| CAS | 328543-09-5 |
| MW: | 320.39 D |
From 45.00€
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