Enhancer of myocardial regenerative repair by stem cells, Potent inducer of Nkx2,5 and a subset of other cardiac markers, including myocardin, and sarcomeric-tropomyosin (SalphaTM) in a variety of different stem/progenitor cells.

Shz-1 is a Shz that activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations. In addition, Shz-1 drives differentiation of human peripheral blood mononuclear cells, mobilized by granule colony-stimulating...