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Item number: Cay21900-1

GRI-977143 is an agonist of G protein-coupled lysophosphatidic acid receptor 2 (LPA2) with an EC50 value of 3.3 µM in LPA2-transfected RH7777 cells. It is selective for LPA2, having no activity at LPA1, LPA3, LPA4, and LPA5 at concentrations up to 10 µM. GRI-977143 increases growth and reduces caspase-3 and -7...

Keywords:	2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]-benzoic acid
Application:	LPA2 receptor agonist
CAS	325850-81-5
MW:	391.4 D

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GRI977143

Item number: TGM-T22812-100mg

Description: GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 µM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragmentation. Target: LPA Receptor. Smiles: OC(=O)c1ccccc1SCCCN1C(=O)c2cccc3cccc(C1=O)c23. References: Gyöngyi N. Kiss, et al. Virtual Screening for...

Keywords:	GRI 977143
CAS	325850-81-5
MW:	391.44 D

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