Description: BLT-1 is a scavenger receptor BI (SR-BI)inhibitor. Target: Others, HCV Protease. Smiles: CCCCCCC1CCC\C1=N\NC(N)=S. References: Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26,99(24):15422-7.

BLT-1 is an inhibitor of scavenger receptor B1 (SR-BI). It inhibits uptake of [3H]cholesteryl ester-HDL in LDL receptor-deficient CHO cells expressing mouse SR-BI ((ldlA[mSR-BI]) cells, IC50 = 0.11 µM) and the efflux of cholesterol from ldlA[mSR-BI] cells to HDL (IC50 = 0.15 µM). BLT-1 (8 µM) induces developmental...