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JK 184
Item number: Cay15265-1
JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184...
| Keywords: | N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine |
| Application: | Adh7 / microtubule depolymerization / Gli inhibitor |
| CAS | 315703-52-7 |
| MW: | 350.4 D |
From 49.00€
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JK184
Item number: TGM-T3588-100mg
Description: JK184, a potent Hedgehog (Hh) pathway inhibitor. Target: Hedgehog/Smoothened. Smiles: CCOc1ccc(Nc2nc(cs2)-c2c(C)nc3ccccn23)cc1
| Application: | Adh7 / microtubule depolymerization / Gli inhibitor |
| CAS | 315703-52-7 |
| MW: | 350.44 D |
From 30.00€
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