Description: RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies. Target: DNA/RNA Synthesis. Smiles: Brc1ccc(NC(=O)c2ccc(Br)c(c2)S(=O)(=O)NCc2ccccc2)cc1. References: Jayathilaka K, et al. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc...

RS-1 is an activator of DNA repair protein RAD51 (Kd = 48-107 for human RAD51 with different cofactors present). It stimulates homologous strand assimilation activity at least 5- to 11-old, enhancing homologous recombination activity of hRAD51. RS-1 is a potent enhancer of CRISPR-mediated genome editing, increasing...