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M2I-1
Item number: Cay22297-10
M2I-1 is an inhibitor of the protein-protein interaction between the spindle assembly checkpoint protein mitotic arrest deficient 2 (Mad2) and cell division cycle 20 (Cdc20), a coactivator of the anaphase-promoting complex/cyclosome (APC/C). It inhibits Mad2 binding to Cdc20111-138 when used at concentrations...
| Keywords: | 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione |
| Application: | Mad2 Cdc20 protein-protein interaction inhibitor |
| CAS | 312271-03-7 |
| MW: | 404.5 D |
From 49.00€
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M2I-1
Item number: TGM-T4647-100mg
Description: M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. It can also inhibited the Mad2-F-Mbp1...
| Keywords: | M2I 1 |
| Application: | Mad2 Cdc20 protein-protein interaction inhibitor |
| CAS | 312271-03-7 |
| MW: | 404.48 D |
From 33.00€
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