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Item number: Cay19093-10

BMI1/RING1A and BMI1/RNF2 are E3 ubiquitin ligase complexes that mediate the monoubiquitination of histone 2A (H2A). This is an essential function of polycomb repressive complex 1 (PRC1). PRT4165 is an inhibitor of the ubiquitin ligase activity of PRC1. It blocks BMI1/RING1A self-ubiquitination (IC50 = 3.9 µM), as...

Keywords:	NSC 600157, 2-(3-pyridinylmethylene)-1H-indene-1,3(2H)-dione
Application:	BMI1/RING1A & BMI1/RNF2 inhibitor
CAS	31083-55-3
MW:	235.2 D

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PRT4165

Item number: TGM-T3110-100mg

Description: PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor. Target: Others, BMI-1, E1/E2/E3 Enzyme. Smiles: O=C1C(=Cc2cccnc2)C(=O)c2ccccc12. References: Ismail, et al. J Biol Chem. 2013 Sep 13,288(37):26944-54.

Keywords:	NSC600157, PRT 4165
Application:	BMI1/RING1A & BMI1/RNF2 inhibitor
CAS	31083-55-3
MW:	235.24 D

From 37.00€ *

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