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Cyclopamine-KAAD
Item number: Cay20943-1
Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic...
| Keywords: | N-[6-[[2-[(3'R,3'aS,6'S,6aS,6bS,7'aR,2'R,11aS,11bR)-1,2,3,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6'... |
| Application: | Specific hedgehog signaling inhibtor |
| CAS | 306387-90-6 |
| MW: | 698 D |
From 712.00€
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KAAD-Cyclopamine
Item number: TGM-T35558-1mg
Description: Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the...
| CAS | 306387-90-6 |
| MW: | 697.99 D |
2,057.00€
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3-Keto-N-aminoethyl-N'-aminoca proyldihydrocinnamoyl...
Item number: K0292.1
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and sonic hedgehog intracellular signaling. The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of beta-Galactosidase expression in Ptch(-/-) cells....
| Application: | Blocking of sonic hedgehog signaling |
| CAS | 306387-90-6 |
| MW: | 697,99 D |
675.00€
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