6 products were found matching "30562-34-6"!

2.5 µmol/L. A novel geldanamycin fluorescent probe optimized for use with BPS's HSP90 kits (linked). May also be used for detection of cell surface HSP90. Supplied as: DMSO solution (2.5 µM). Avoid freeze/thaw cycles. Keep DMSO stock solutions out of contact with air. Protect from light.

Description: Geldanamycin, an HSP90 inhibitor (Kd: 1.2 µM), specifically disrupts glucocorticoid receptor (GR)/HSP association. Target: Influenza Virus, Antibacterial, HSP, Tyrosine Kinases, Antibiotic. Smiles:...

Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions. Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression,...

Isolated from Streptomyces hygroscopicus. Soluble in methanol or DMSO, insoluble in water. Antibiotic. Potent antitumor compound. pp60src tyrosine kinase inhibitor. Inhibits c-mycgene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src and yes. Binds specifically to...

Geldanamycin binds specifically to heat shock protein HSP90, inhibits protein maturation. Melting Point: 261-266.5ºC, Elemental Analysis: Calculated, C: 60.19%, H: 7.32%, N: 4.84, Solubility: Soluble in DMSO at 100mg/ml. Poorly soluble in methanol, ethanol and water, Not recommended for stock solutions. Maximum...

A benzoquinoid ansamycin antibiotic having antitumor activities. It suppresses DNA replication by inhibiting c-myc gene expression in lymphoblastoma L5178Y cells. It inhibits tyrosine kinases and induces increased p53 protein involved in cell-cycle arrests of human ovarian tumor cells. It inhibits the 90 kDa heat...