Soluble in DMSO or ethanol. TAK-715 is a potent specific inhibitor of the p38alpha MAP kinase with an IC(50) of 7.1nM. It is approximately 30-fold more selective for p38alpha over p38beta. It shows no inhibition of p38gamma/delta. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine

TAK-715 is an inhibitor of p38alpha MAPK (IC50 = 7.1 nM). It is selective for p38alpha over p38beta (IC50 = 200 nM), as well as over p38gamma/delta, JNK, ERK1, IKKbeta, MEKK1, and TAK1 (IC50 = >10 µM for all) but also inhibits casein kinase Idelta (CK1delta) and CK1epsilon. It inhibits TNF-alpha release induced by...