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Item number: Cay45393-1

A PROTAC that drives mutant EGFR degradation, selectively induces degradation of mutant EGFRs over wild-type EGFR (DC50s = 10.2, 36.5, 88.5, 75.4, and >300 nM for EGFRL858R/T790M/C797S, EGFRDelta19/T790M/C797S, EGFRL858R/T790M, EGFRDelta19, and wild-type EGFR, respectively), inhibits the growth of H1975 cells...

Keywords:	Proteolysis-targeting Chimera EGFR Degrader-9, Proteolysis-targeting Chimera Epidermal Growth Factor Receptor Degrader-9,...
Application:	Mutant EGFR degradation driving PROTAC
CAS	2992670-33-2
MW:	899.99 D

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