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Item number: Cay42962-10

ML-402 is an activator of the two-pore domain potassium channels K2P2.1/TREK-1 and K2P10.1/TREK-2. It selectively activates K2P2.1/TREK-1 and K2P10.1/TREK-2 expressed in Xenopus oocytes (EC50s = 13. and 5. µM, respectively) over K2P4.1/TRAAK expressed in Xenopus oocytes at 100 µM.. Solulibility: DMSO: Soluble: = 10...

Keywords:	N-[2-(4-chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide
Application:	K2P2.1/TREK-1 / K2P10.1/TREK-2 activator
CAS	298684-44-3
MW:	295.78 D

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ML402

Item number: TGM-T16109-100mg

Description: ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 µM and 5.9 µM. Target: Potassium Channel. Smiles: Cc1cc(Cl)ccc1OCCNC(=O)c1cccs1. References: Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul...

Keywords:	N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide, ZINC3671497
CAS	298684-44-3
MW:	295.78 D

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