Cytochrome P450 3A4 inducing anti-epileptic drug. It Increases metabolism of CPT11 and Paclitaxel, and many tyrosine kinase inhibitors. Used in the treatment of shooting neuralgic pain attacks.

Carbamazepine (CRM) (Cay-42589) is a certified reference material categorized as a sodium channel inhibitor. Carbamazepine has been found as an adulterant in dietary supplements and heroin samples seized by law enforcement. Formulations containing carbamazepine have been used in the treatment of seizures, trigeminal...

Carbamazepine is an inhibitor of sodium channels. It preferentially inhibits inactivated voltage-gated sodium channel Nav1.7 and Nav1.3 (IC50s = 406 and 900 µM, respectively) over resting (closed) Nav1.7 and Nav1.3 channels in whole-cell patch-clamp assays using HEK293 cells (IC50s = 1,584 and 2,464 µM,...

Description: Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation. Its analgesic activity is not...