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Item number: Cay45613-1

HD-TAC7 is a proteolysis-targeting chimera (PROTAC) composed of a class I histone deacetylase (HDAC) inhibitor linked to the cereblon ligand pomalidomide (Cay19877). It binds to HDAC1, HDAC2, and HDAC3 (IC50s = 3.6, 4.2, and 1.1 µM, respectively) and induces degradation of HDAC3 in RAW 264.7 cells with a...

Keywords:	N-(2-amino-4-fluorophenyl)-4-[[5-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetyl]-am...
Application:	HDAC3 degradation driving PROTAC
CAS	2978763-95-8
MW:	657.66 D

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