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Item number: Cay11899-1

Hymeglusin is a fungal beta-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 µM) by covalently modifying the active Cys129 residue of the enzyme. At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%. Chiral studies indicate that the (2R,3R)-beta-lactone moiety of...

Keywords:	Antibiotic 1233A, Antibiotic F 244, L 659,699,...
Application:	HMG-CoA synthase inhibitor, Antibiotic
CAS	29066-42-0
MW:	324.4 D

From 157.00€ *

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(R, R)-Hymeglusin

Item number: AG-CN2-0103-M001

Beta-Lactone antibiotic, antibacterial and antifungal, specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active Cys129 residue of the enzyme, mevalonate biosynthesis inhibitor

Keywords:	1233A, F-244, L-659-699
Application:	HMG-CoA synthase inhibitor
CAS	29066-42-0
MW:	324,4 D

From 176.00€ *

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