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Item number: Cay44291-1

JAB-2485 is an inhibitor of Aurora A kinase (IC50 = 0. nM). It is selective for Aurora A over Aurora B and Aurora C kinases at 2 µM. JAB-2485 decreases levels of phosphorylated Aurora A kinase in NCI H446 small-cell lung cancer cells (IC50 = 2. nM) and reduces the viability of 11 lung cancer cell lines (IC50s =...

Keywords:	1-[(3-chloro-2-fluorophenyl)methyl]-4-[[5-fluoro-4-methyl-6-[(3-methyl-1H-pyrazol-5-yl)amino]-2-pyridinyl]methyl]-2-methyl...
Application:	Aurora A kinase inhibitor
CAS	2899209-55-1
MW:	503.98 D

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