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Item number: Cay22961-10

SB-408124 is a potent antagonist of orexin 1 receptors (OX1Rs) with a Ki value of 26.9 nM in a calcium mobilization assay using CHO cells that stably express human OX1R. It is selective for OX1R over OX2R, with Kd values of 21.7 and 1,704 nM, respectively, in a radioligand binding assay. In vivo co-perfusion of...

Keywords:	N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]-urea
Application:	OX1R antagonist
CAS	288150-92-5
MW:	356.4 D

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SB-408124

Item number: TGM-T6658-10mg

Description: SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. Target: OX Receptor. Smiles: CN(C)c1ccc(NC(=O)Nc2cc(C)nc3c(F)cc(F)cc23)cc1. References: Langmead CJ, et al, Br J Pharmacol,...

Application:	OX1R antagonist
CAS	288150-92-5
MW:	356.37 D

From 39.00€ *

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