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PD 180970
Item number: Cay30619-1
PD 180970 is an inhibitor of Bcr-Abl. It inhibits wild-type and mutant forms of Bcr-Abl, as well as the p210 isoform, a marker of chronic myelogenous leukemia (CML), with IC50 values ranging from 5 to 48 nM. PD 180970 is selective for Bcr-Abl over basic FGFR (bFGFR) and PDGFR (IC50s = 934 and 1,430 nM, respectively)...
| Keywords: | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Application: | Bcr-Abl inhibitor |
| CAS | 287204-45-9 |
| MW: | 429.3 D |
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PD180970
Item number: TGM-T23128-100mg
Description: PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies about chronic myelogenous leukemia. Target: c-Kit, Bcr-Abl, Src. Smiles: Cc1cc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)ccc1F. References: J...
| Keywords: | PD 180970 |
| CAS | 287204-45-9 |
| MW: | 429.27 D |
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