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Item number: Cay45614-1

SKLB03220 is a covalent inhibitor of the histone-lysine methyltransferase enhancer of zeste homolog 2 (EZH2, IC50 = 1.72 nM). It also inhibits EZH2A677G, EZH2Y641N, and EZH2Y641F, mutations found in various cancers, when used at a concentration of 10 nM. SKLB03220 is selective for EZH2 over a variety of other...

Keywords:	N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2',4-dimethyl-5'-[(1-oxo-2...
Application:	Covalent EZH2 inhibitor
CAS	2852050-29-2
MW:	556.71 D

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