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Item number: Cay45519-1

PLX3618 is a monovalent direct degrader of bromodomain-containing protein 4 (BRD4). It binds to both bromodomain 1 (BD1) and BD2 of BRD4 and mediates its degradation via recruitment of the E3 ubiquitin ligase DDB1- and CUL4-associated factor 11 (DCAF11) with a half-maximal degradation concentration (DC50) value of...

Keywords:	(6S)-2,3,9-trimethyl-4-[3'-[(pyrazolo[1,5-a]pyrimidin-3-ylcarbonyl)amino][1,1'-biphenyl]-4-yl]-6H-thieno[3,2-f][1,2,4]tria...
Application:	Monovalent direct BRD4 degrader
CAS	2851986-76-8
MW:	601.69 D

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