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Item number: TGM-T64355-100mg

Description: TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10), displaying nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 = 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound....

Application:	Soluble adenylyl cyclase inhibitor
CAS	2810887-45-5
MW:	313.78 D

From 37.00€ *

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TDI-10229

Item number: Cay37674-1

TDI-10229 is an inhibitor of soluble adenylyl cyclase (sAC, IC50 = 0.2 µM for the human enzyme in a cell-free assay). It is selective for sAC over the transmembrane ACs AC1-3, -5, -8, and -9 at 10 µM. TDI-10229 inhibits cAMP accumulation induced by the phosphodiesterase (PDE) inhibitor IBMX (Cay-13347) in rodent...

Keywords:	4-chloro-6-[1,5-dimethyl-4-(phenylmethyl)-1H-pyrazol-3-yl]-2-pyrimidinamine
Application:	Soluble adenylyl cyclase inhibitor
CAS	2810887-45-5
MW:	313.8 D

From 41.00€ *

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