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Item number: Cay43038-10

MTX-531 is an EGFR antagonist and PI3K inhibitor. It selectively inhibits EGFR over HER2 and HER4 (IC50s = 14. 2,500, and >10,000 nM, respectively) and PI3Kdelta, PI3Kalpha, and PI3Kgamma over PI3Kbeta (IC50s = 1. 6. 8. and 233 nM, respectively) but also inhibits DNA-dependent protein kinase (DNA-PK, IC50s = 5. nM)....

Keywords:	N-[2-chloro-5-[4-[[(1R)-1-phenylethyl]amino]-6-quinazolinyl]-3-pyridinyl]-methanesulfonamide
Application:	EGFR antagonist, PI3K inhibitor
CAS	2791417-66-6
MW:	453.95 D

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