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GW 4064
Item number: Cay10006611-5
Farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity. GW 4064 is a selective agonist of FXR (EC50 = 15 nM). It displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 µM. GW...
| Keywords: | 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-benzoic acid |
| Application: | FXR agonist |
| CAS | 278779-30-9 |
| MW: | 542.8 D |
From 49.00€
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GW 4064
Item number: TGM-T2233-100mg
Description: GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM). Target: Autophagy, FXR. Smiles: CC(C)c1onc(c1COc1ccc(C=Cc2cccc(c2)C(O)=O)c(Cl)c1)-c1c(Cl)cccc1Cl. References: Akwabi-Ameyaw A et al., Bioorg Med Chem Lett, 2008, 18(15), 4339-4343.
| Application: | FXR agonist |
| CAS | 278779-30-9 |
| MW: | 542.84 D |
From 44.00€
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