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Item number: Cay45375-1

(R)-STU104 is an inhibitor of the protein-protein interaction between TGF-beta-activated kinase 1 (TAK1) and MAP kinase kinase 3 (MKK3). It binds MKK3 (KD = 71 nM), inhibits the phosphorylation of MKK3 in RAW 264.7 macrophages (IC50 = 4 µM), and disrupts the interaction between MKK3 and TAK1 in the same cells....

Keywords:	(3R)-2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-1H-inden-1-one
Application:	TAK1-MKK3 protein-protein interaction inhibitor
CAS	2767124-77-4
MW:	298.34 D

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(R)-STU104

Item number: TGM-T60657-10mg

Description: (R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-alpha and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathway by binding to MKK3 and disrupting TAK1 phosphorylation of MKK3. (R)-STU104 is a candidate compound for the treatment of ulcerative...

CAS	2767124-77-4
MW:	298.33 D

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