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Item number: Cay43720-1

TMX-4116 is a casein kinase 1alpha (CK1alpha) degrader. It selectively induces E3 ubiquitin ligase-mediated degradation of CK1alpha over phosphodiesterase 6D (PDE6D), Ikaros family zinc finger protein 1 (IKZF1), and IKZF3 in MM.1S cells when used at concentrations ranging from 0.04 to 1 µM. SMILES...

Keywords:	3-[4-[4-methoxy-5-(1-pyrrolidinylcarbonyl)-3-thienyl]-1H-1,2,3-triazol-1-yl]-2,6-piperidinedione
Application:	CK1alpha degrader
CAS	2766385-56-0
MW:	389.43 D

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TMX-4116

Item number: TGM-T61754-25mg

Description: TMX-4116, a casein kinase 1alpha (CK1alpha) degrader, preferentially degrades CK1alpha in MOLT4, Jurkat, and MM.1S cells, exhibiting degradation concentration 50s (DC50s) below 200 nM. TMX-4116 is utilized in the research of multiple myeloma [1]. Target: Others. Smiles:...

CAS	2766385-56-0
MW:	389.43 D

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