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Item number: Cay44459-1

STX-721 is an irreversible inhibitor of EGFR with an exon 20 insertion (ex20ins) mutation. It selectively inhibits the proliferation of Ba/F3 cells expressing EGFR exon20 A769_V770 insASV and EGFR exon20 D770_N771 insSVD (IC50s = 5. and 5. nM, respectively) over those expressing wild-type EGFR (IC50 = 127. nM)....

Keywords:	3-[(3-chloro-2-methoxyphenyl)amino]-2-[3-[2-[(2R)-1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-2-methyl-2-pyrrolidinyl]et...
Application:	Irreversible EGFR ex20ins inhibitor
CAS	2765525-82-2
MW:	587.12 D

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