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Gambogic Acid
Item number: Cay14761-1
Gambogic acid (GA) is a xanthonoid that has been found in G. hanburyi resin and has anticancer activity. It binds covalently to the regulatory subunit B (SPTSSB) of the serine palmitoyltransferase complex (Ki = 1.5 µM, kinact = 0.05 min-1) and inhibits de novo sphingolipid biosynthesis. GA activates caspases in T47D...
| Keywords: | GA, beta-Guttiferin,... |
| Application: | Caspase activator |
| CAS | 2752-65-0 |
| MW: | 628.8 D |
From 50.00€
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Gambogic acid
Item number: LKT-G0248.100
Gambogic acid is a xanthonoid isolated from the brownish or orange resin from Garcinia hanburyi. Its anticancer activities are due to apoptosis induction, inhibition of topoisomerase and telomerase, and angiogenesis modification.
| Keywords: | 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid, B''-Guttiferrin, Beta-Guttiferrin,... |
| Application: | Apoptosis inducer |
| CAS | 2752-65-0 |
| MW: | 628.75 D |
From 179.00€
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Gambogic Acid
Item number: TGM-T6185-1mL
Description: Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively. Target:...
| Keywords: | Guttic Acid, Guttatic Acid, Beta-Guttiferrin |
| Application: | Caspase activator |
| CAS | 2752-65-0 |
| MW: | 628.75 D |
From 32.00€
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