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P053
Item number: Cay26113-1
P053 is an inhibitor of ceramide synthase 1 (CerS1, IC50s = 0.54 and 0.46 µM for human and mouse CerS1, respectively). It is selective for CerS1 over CerS2, CerS4, CerS5, and CerS6 (IC50s = 28.6, 17.2, 7.2, and 11.4 µM, respectively). P053 decreases the production of C18 ceramide (Cay-19556) from dihydrosphingosine...
| Keywords: | (S)-2-amino-4-(4-((3,4-dichlorobenzyl)oxy)phenyl)-2-methylbutan-1-ol |
| Application: | CerS1 inhibitor |
| CAS | 2748196-63-4 |
| MW: | 354.3 D |
From 157.00€
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P053
Item number: TGM-T12342-10mg
Description: P053 is a potent, non-competitive, and selective ceramide synthase 1 (CerS1) inhibitor with an IC50 of 0.5 µM. It acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle and regulates whole-body adiposity[1]. Target: Others. Smiles: C[C@@](N)(CO)CCc1ccc(OCc2ccc(Cl)c(Cl)c2)cc1....
| Application: | CerS1 inhibitor |
| CAS | 2748196-63-4 |
| MW: | 354.27 D |
From 345.00€
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