Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi...

Is a biologically active shingolipid metabolite generated by enzymatic cleavage of stores of sphingomyelin in membraines of stimulated cells. It induces programmed cell death (apoptosis) which is associated with enhanced expression of bax protein. Regulation of bax gene expression by shingosine-1-phosphate is...