AICAR is an activator of AMP-activated protein kinase (AMPK). It increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 µM) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of control cells and...

Soluble in water (9 mg/ml), DMSO or dimethyl formamide. Cell permeable AMP-activated protein kinase (AMPK) activator. Insulin mimetic. Adipocyte differentiation inhibitor. Apoptosis inducer. PPARalpha inhibitor. mTOR inhibitor. P70S6K inhibitor. LPS-induced TNF-alpha production inhibitor. TORC2...

Soluble in DMSO at 40 mg/mL, soluble in ethanol at 2 mg/mL with warming, soluble in water at 20 mg/mL with warming, buffers, serum, or other additives may increase or decrease the aqueous solubility

AMPK activator

Melting Point: , As Reported, Solubility: As Reported, Method for Determining Identity: Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis, TLC Conditions: As Reported, Specific Rotation: As Reported, Elemental Analysis: As Reported, Storage and Stability: May be stored at RT for short-term only....