AICAR is an activator of AMP-activated protein kinase (AMPK). It increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 µM) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of control cells and...

Soluble in water (9 mg/ml), DMSO or dimethyl formamide. Cell permeable AMP-activated protein kinase (AMPK) activator. Insulin mimetic. Adipocyte differentiation inhibitor. Apoptosis inducer. PPARalpha inhibitor. mTOR inhibitor. P70S6K inhibitor. LPS-induced TNF-alpha production inhibitor. TORC2...

AMPK activator

Description: AICAR (Acadesine) is an AMPK activator that causes ZMP accumulation, thereby mimicking the stimulatory effect of AMP on both AMPK and AMPKK. It is commonly used in research related to diabetes, cardiovascular diseases, and tumors. Target: Autophagy, Mitophagy, AMPK, YAP. Smiles:...

Melting Point: , As Reported, Solubility: As Reported, Method for Determining Identity: Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis, TLC Conditions: As Reported, Specific Rotation: As Reported, Elemental Analysis: As Reported, Storage and Stability: May be stored at RT for short-term only....