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Item number: Cay42904-1

ART812 is an inhibitor of DNA polymerase theta (IC50 = 7. nM). It inhibits microhomology-mediated end joining (MMEJ) in a reporter assay using HEK293 cells (EC50 = 240 nM). ART812 (150 mg/kg twice per day) increases blood levels of micronucleated reticulocytes in mice. It inhibits tumor development in a Brca1- and...

Keywords:	(2S,3S,4S)-N-(3-chloro-4-fluorophenyl)-3,4-dihydroxy-N-methyl-1-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-5-oxo-2-pyrroli...
Application:	DNA polymerase theta (POLQ) inhibitor
CAS	2607138-82-7
MW:	461.8 D

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ART812

Item number: TGM-T40236-100mg

Description: ART812 is an orally active inhibitor of DNA polymerase Poltheta, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM. Target: DNA/RNA Synthesis. Smiles:...

Keywords:	ART812
CAS	2607138-82-7
MW:	461.79 D

From 111.00€ *

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