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Item number: Cay42324-10

ART558 is an inhibitor of DNA polymerase theta (Poltheta, IC50 = 7. nM for Poltheta polymerase activity). It is selective for the polymerase activity of Poltheta over its ATPase activity (IC50 = >12 µM). ART558 (0. 0. and 1 µM) inhibits the repair of DNA double-strand breaks via theta-mediated end joining (TMEJ),...

Keywords:	(2S,3R)-1-[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]-3-hydroxy-N-methyl-N-(3-methylphenyl)-2-pyrrolidinecarboxamide
Application:	DNA polymerase theta inhibitor
CAS	2603528-97-6
MW:	418.41 D

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ART558

Item number: TGM-T9275-100mg

Description: ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Poltheta inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer. Target: DNA/RNA Synthesis. Smiles: CN(C(=O)[C@@H]1[C@H](O)CCN1c1nc(C)cc(c1C#N)C(F)(F)F)c1cccc(C)c1. References: Rodriguez-Berriguete...

CAS	2603528-97-6
MW:	418.41 D

From 146.00€ *

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