4 products were found matching "257933-82-7"!
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Pelitinib
Item number: LKT-P1845.5
EGFR inhibitor.
| Keywords: | EKB-569, (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide |
| Application: | Epidermal growth factor receptor (EGFR) inhibitor |
| CAS | 257933-82-7 |
| MW: | 467.92 D |
From 177.00€
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Pelitinib
Item number: Cay15627-1
Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM). It inhibits HER2 with a much weaker potency (IC50 = 1.2 µM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong...
| Keywords: | EKB-569, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2E-butenamide |
| Application: | EGFR inhibitor |
| CAS | 257933-82-7 |
| MW: | 467.9 D |
From 67.00€
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Pelitinib
Item number: SYN-1141-M001
Soluble in DMSO or ethanol. Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells...
| Keywords: | EKB-569 |
| Application: | EGFR inhibitor |
| CAS | 257933-82-7 |
| MW: | 467,9 D |
From 123.00€
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Pelitinib
Item number: TGM-T2327-100mg
Description: Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM). Target: MEK, EGFR, Raf, Src. Smiles: CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C. References: Torrance CJ, et al. Nat Med, 2000, 6(9), 1024-1028.
| Keywords: | EKB-569, WAY-EKB 569 |
| Application: | Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1) |
| CAS | 257933-82-7 |
| MW: | 467.92 D |
From 41.00€
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