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Item number: Cay33429-1

Sparsentan is a dual antagonist of angiotensin II type 1 (AT1) and endothelin receptor type A (ETA, Kis = 0.8 and 9.3 nM, respectively, for the human receptors). It is selective for these receptors over AT2 and ETB receptors (Kis = >10 µM for both). Sparsentan inhibits angiotensin II-induced pressor responses in...

Keywords:	4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-[1,1'-biphenyl...
Application:	AGTR1 / EDNRA dual antagonist
CAS	254740-64-2
MW:	592.8 D

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