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Hydroxy Bosentan
Item number: Cay22366-1
Hydroxy bosentan is an active phase I metabolite of bosentan (Cay-11731) produced by the cytochrome P450 isoforms CYP3A4 and CYP2C9. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM). Up to 20% of the activity of bosentan may be due to the action of hydroxy bosentan...
| Keywords: | Ro 48-5033, Ro 48-8634,... |
| Application: | Active metabolite, endothelin receptor antagonist |
| CAS | 253688-60-7 |
| MW: | 567.6 D |
From 172.00€
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Hydroxy bosentan
Item number: TGM-T19360-1mg
Description: Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver, assisting BOS pharmacologically with 10%-20% activity retention. Target: Others. Smiles: O=S(=O)(NC=1N=C(N=C(OCCO)C1OC=2C=CC=CC2OC)C3=NC=CC=N3)C4=CC=C(C=C4)C(C)(C)CO....
| Keywords: | Ro 48-5033 |
| Application: | Active metabolite, endothelin receptor antagonist |
| CAS | 253688-60-7 |
| MW: | 567.61 D |
From 272.00€
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