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AZD 7545
Item number: Cay19282-5
AZD 7545 is an inhibitor of pyruvate dehydrogenase (PDH) kinases (PDKs), resulting in an increase in PDH activity with an EC50 value of 5.2 nM for PDK2. It less potently inhibits PDK1 and PDK3 (IC50s = 87 and 600 nM, respectively). AZD 7545 stimulates pyruvate oxidation in rat hepatocytes (EC50 = 105 nM) and...
| Keywords: | 4-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethyl-benzamide |
| Application: | Pyruvate dehydrogenase kinase (PDK) inhibitor |
| CAS | 252017-04-2 |
| MW: | 478.9 D |
From 55.00€
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AZD-7545
Item number: AG-CR1-3692-M005
Potent and selective pyruvate dehydrogenase kinase 2 (PDK2) inhibitor (IC50=6.4nM), consequently increasing pyruvate dehydrogenase (PDH) activity. Less potent inhibitor towards PDK1 and PDK3 (IC50=87 and 600nM, respectively). Inhibitor of glycolysis. Antiobesity and antidiabetic agent. Improves blood glucose control...
| Keywords: | 4-[[3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethyl-benzamide |
| Application: | Potent, selective pyruvate dehydrogenase kinase 2 (PDK2) inhibitor |
| CAS | 252017-04-2 |
| MW: | 478.9 D |
From 44.00€
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AZD7545
Item number: TGM-T2447-5mg
Description: AZD7545 is a potent PDHK inhibitor. Target: Dehydrogenase. Smiles: CN(C)C(=O)c1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c1. References: Morrell JA, et al. Biochem Soc Trans. 2003, 31(Pt 6), 1168-1170.
| CAS | 252017-04-2 |
| MW: | 478.87 D |
From 42.00€
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