3 products were found matching "2490599-18-1"!
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GMB-475
Item number: TGM-T8488-100mg
Description: GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein. Target: PROTACs,...
| Application: | Protac(R) reagent |
| CAS | 2490599-18-1 |
| MW: | 861.93 D |
From 88.00€
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GMB 475
Item number: Cay40463-10
GMB 475 is a proteolysis-targeting chimera (PROTAC) containing the Bcr-Abl inhibitor GNF-5 (Cay-16254) conjugated to VHL ligand 1 (Cay-21591). It induces degradation of Bcr-Abl with a half-maximal degradation concentration (DC50) value of 340 nM. GMB 475 selectively inhibits the proliferation of K562 chronic myeloid...
| Keywords: | (4R)-3-methyl-N-[2-[2-[4-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]phenoxy]ethoxy]acetyl]-L-valyl-4-hydroxy-N-[... |
| Application: | Bcr-Abl degradation driving PROTAC |
| CAS | 2490599-18-1 |
| MW: | 861.9 D |
From 102.00€
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GMB-475
Item number: BPS-82054
GMB-475 acts as a degrader of BCR-ABL 1 tyrosine kinase and as a recruiter of the E3 ligase Von Hippel Lindau (VHL) resulting in ubiquitination and subsequent degradation of oncogenic fusion proteins.
| Application: | Protac(R) reagent |
| CAS | 2490599-18-1 |
| MW: | 861,9 D |
954.00€
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