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GEM144
Item number: Cay44647-1
GEM144 is a dual inhibitor of DNA polymerase alpha (POLA1) and histone deacetylase 11 (HDAC11). It inhibits the primer extension activity of POLA1 in a cell-free assay when used at concentrations ranging from 10 to 50 µM and increases acetylation of alpha-tubulin at lysine 40 in H460 lung cancer cells at 0.4 µM. It...
| Keywords: | (2E)-3-[4'-[2-(hydroxyamino)-1-methyl-2-oxoethoxy]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-2-propenoic acid |
| Application: | POLA1 / HDAC11 dual inhibitor |
| CAS | 2487526-28-1 |
| MW: | 461.56 D |
From 69.00€
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GEM144
Item number: TGM-T62916-100mg
Description: GEM144 is a potent, orally active dual inhibitor of DNA polymerase alpha (POLA1) and HDAC 11. GEM144 induces p53 acetylation, activates p21, blocks the cell cycle in G1/S phase and induces apoptosis. Target: Others. Smiles: O(C(C(NO)=O)C)C1=C(C23CC4CC(C2)CC(C3)C4)C=C(C=C1)C5=CC=C(/C=C/C(O)=O)C=C5
| CAS | 2487526-28-1 |
| MW: | 461.55 D |
From 2,029.00€
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