Fimasartan is an antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 0.16 nM in HEK293 cells expressing the human receptor). It is selective for the AT1- over the AT2 receptor (IC50 = 69 µM). Fimasartan (62.5, 125, and 250 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) levels...

Description: Fimasartan (BR-A-657) is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has shown to be safe in clinical trials. Target: Apoptosis, RAAS. Smiles:...