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Item number: Cay45383-1

NV03 is an inhibitor of the protein-protein interaction between E3 ubiquitin-protein ligase UHRF1 (UHRF1) and histone H3 trimethylated lysine 9 (H3K9Me3). It binds the tandem Tudor domain (TTD) of UHRF1 (Kd = 2.4 µM) and is selective for the UHRF1-TTD over a panel of 36 demethylases at 10 µM.. SMILES:...

Keywords:	N-[3-(diethylamino)propyl]-5,9-dimethyl-8-oxo-thieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine-7(8H)-acetamide
Application:	UHRF1-H3K9Me3 protein-protein interaction inhibitor
CAS	2448341-58-8
MW:	389.52 D

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NV03

Item number: TGM-T12271-25mg

Description: NV03 is a potent and selective antagonist of the UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)-H3K9me3 interaction, binding to the UHRF1 tandem tudor domain with a Kd of 2.4 µM. NV03 holds potential as an anticancer therapeutic [1]. Target: Others. Smiles:...

CAS	2448341-58-8
MW:	389.52 D

1,289.00€ *

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