KT474 is a proteolysis-targeting chimera (PROTAC) that drives the degradation of IL-1 receptor-associated kinase 4 (IRAK4). It induces the degradation of IRAK4 in primary mouse and rat splenocytes and isolated dog, monkey, and human peripheral blood mononuclear cells (PBMCs) with half-maximal degradation...

Description: PROTAC IRAK4 degrader-7 (Compound I-417) is an orally administered agent with antitumor properties, functioning as a PROTAC IRAK4 degrader [1]. Target: PROTACs. Smiles: [H][C@@]12CN(c3ccn4ncc(C(=O)Nc5cn(nc5C(F)F)[C@H]5CC[C@H](CN6CCC(CC6)OCC#Cc6cccc7n(C8CCC(=O)NC8=O)c(=O)n(C)c67)CC5)c4n3)[C@@]([H])(CO1)C2