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Item number: Cay16004-1

The sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis. It plays an important role in the myocardial response to ischemia-reperfusion. Zoniporide inhibits human NHE-1 with an IC50 value...

Keywords:	CP 597,396, N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide, monohydrochloride
Application:	Na+-H+ exchange subtype 1 (NHE-1) inhibitor
CAS	241800-97-5
MW:	356.8 D

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Zoniporide hydrochloride

Item number: TGM-T21996-10mg

Description: Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of human platelets. Target: Sodium Channel. Smiles:...

Keywords:	CP-597396 hydrochloride
CAS	241800-97-5
MW:	356.81 D

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