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Item number: Cay39158-10

SR 4835 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13. It binds to Cdk12 and Cdk13 (Kds = 98 and 4.9 nM, respectively) and inhibits Cdk12- and Cdk13-dependent phosphorylation of RNA polymerase II in MDA-MB-231 cells (EC50 = 105.5 nM). SR 4835 inhibits the proliferation of MDA-MB-231, MDA-MB-468, Hs...

Keywords:	N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine
Application:	Cdk12 / Cdk13 inhibitor
CAS	2387704-62-1
MW:	499.4 D

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