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Item number: TGM-T6301-100mg

Description: Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Intracellularly converted into the poorly membrane-permeable active metabolite (CHR-79888), it inhibits puromycin-sensitive aminopeptidase (PuSA) and leukotriene A4...

Keywords:	CHR-2797
Application:	Targets aminopeptidase N [EC:3.4.11.2] (ANPEP, CD13)
CAS	238750-77-1
MW:	406.47 D

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Tosedostat

Item number: Cay23395-1

Tosedostat is an inhibitor of aminopeptidases (IC50s = 100, 150, and 220 nM for LAP, PUSA, and aminopeptidase N, respectively). It inhibits proliferation of human leukemia cell lines in vitro irrespective of p53, PTEN, or K-RAS mutational status (IC50s = 10-770 nM). Tosedostat induces up-regulation of genes in amino...

Keywords:	CHR-2797, alphaS-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-benzeneacetic acid,...
Application:	Aminopeptidase inhibitor
CAS	238750-77-1
MW:	406.5 D

From 111.00€ *

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